Most conditions are inherited genetic diseases, so a child usually needs stem cells from a sibling or another donor (allogenic stem cell use). In some cases, a child’s own cord blood stem cells can be used (autologous stem cell use). Doctors usually start by looking for a genetically matched family member as the source of stem cells for transplant. Final determination of stem cell use is made by the treating physician. Banking cord blood does not guarantee that treatment will work.
Blood Disorders
E-β+ thalassemia
E-βo thalassemia
HbSC disease
Sickle βo Thalassemia
Sickle-cell anemia (hemoglobin SS)
α-thalassemia major (hydrops fetalis)
β-thalassemia intermedia
β-thalassemia major (Cooley's anemia)
Cancers
Acute lymphoblastic leukemia (ALL)
Acute myeloid leukemia (AML)
Biphenotypic Leukemia
* Burkitt's lymphoma
Chronic myeloid leukemia (CML)
Chronic myelomonocytic leukemia (CMML)
* Hodgkin's lymphoma
Juvenile myelomonocytic leukemia (JMML)
Lymphomatoid granulomatosis
Mixed Lineage Leukemia
Myelodysplastic syndrome (MDS)
* Myelofibrosis
* Neuroblastoma
* Non-Burkitt’s lymphoma
* Non-Hodgkin's lymphoma
* Pediatric Primary CNS Lymphomas
* Wilm's Tumor
Bone Marrow
Failure Syndromes
Amegakaryocytic thrombocytopenia
Autoimmune neutropenia (severe)
Congenital dyserythropoietic anemia
Congenital sideroblastic anemia
Diamond-Blackfan anemia
Dyskeratosis congenita
Evan's syndrome
Fanconi anemia
Glanzmann's disease
Kostmann's syndrome (severe congenital neutropenia)
Severe aplastic anemia
Shwachman syndrome
Thrombocytopenia with absent radius (TAR syndrome)
Metabolic
Disorders
Adrenoleukodystrophy Gaucher's disease (infantile)
Alpha mannosidosis
Beta-mannosidase deficiency (LSD)
Fucosidosis
Gaucher's disease (infantile)
Gunther disease (congenital erythropoietic porphyria)
Hermansky-Pudlak syndrome
Hunter syndrome
Hurler syndrome
Krabbe disease (globoid cell leukodystrophy)
Lesch-Nyhan disease
Maroteaux-Lamy syndrome
Metachromatic leukodystrophy
Mucolipidosis Type II, III
Niemann Pick Syndrome, type A and B
Pyruvate Kinase Deficiency
Sandhoff Syndrome
Sanfilippo syndrome
Sly syndrome
Tay-Sachs Disease
Wolman Syndrome
Immunodeficiencies
Activated PI3K Delta Syndrome (APDS)
Adenosine deaminase deficiency
ALPS
Ataxia telangiectasia
CD25 deficiency
Chronic granulomatous disease
Complete IFN-γ Receptor 2 Deficiency
DADA2 (ADA2 Deficiency)
DiGeorge syndrome
Hyper IgM Syndrome
IPEX syndrome
IKK gamma deficiency
Immune dysregulation polyendocrineopathy
Leukocyte adhesion deficiency
LRBA deficiency
Myelokathexis X-linked immunodeficiency
Omenn's syndrome
Reticular dysplasia
Severe combined immunodeficiency (SCID)
STAT1/STAT3 Gain-of-Function
Thymic dysplasia
Wiskott-Aldrich syndrome
X-linked agammaglobulinemia
X-linked lymphoproliferative disease
X-linked Mucolipidosis, Type II
Other
Epidermolysis bullosa
Hemophagocytic lymphohistiocytosis
Juvenile dermatomyositis
Langerhans cell histiocytosis
Osteopetrosis
Severe Refractory Juvenile Rheumatoid Arthritis
